Optimal constrained candidate selection for opportunistic routing

Abstract-In this paper we address the issue of the optimal candidate-set selection in the opportunistic routing paradigm. More specifically, although several algorithms for selecting the optimal candidate set have been proposed, to the best of our knowledge none of them has never considered the problem of selecting the optimal constrained candidate set, namely the optimal candidate set with a fixed maximum set size. In this paper we contribute to this problem by providing an analytical framework to model both the optimal constrained and unconstrained candidate-set selection. Moreover, we propose two algorithms for optimal candidate-set selection for distance vector routing, one for the constrained and one for the unconstrained case. Simulations based on experimental data validate our proposal. Index Terms-ad hoc networks, opportunistic routing, candidate selection, constrained candidate set size

Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition

Polyphenols represent the most studied class of nutraceuticals that can be therapeutics for a large spectrum of diseases, including cancer. In this study, we investigated for the first time the antitumor activities of polyphenol extract from Annurca apple (APE) in MDA-MB-231 triple negative breast cancer cells, and we explored the underlying mechanisms. APE selectively inhibited MDA-MB-231 cell viability and caused G2/M phase arrest associated with p27 and phospho-cdc25C upregulation and with p21 downregulation. APE promoted reactive oxygen species (ROS) generation in MDA-MB-231 cells while it acted as antioxidant in non-tumorigenic MCF10A cells. We demonstrated that ROS generation represented the primary step of APE antitumor activity as pretreatment with antioxidant N-acetylcysteine (NAC) prevented APE-induced G2/M phase arrest, apoptosis, and autophagy. APE downregulated Dusp-1 and induced a significant increase in JNK/c-Jun phosphorylation that were both prevented by NAC. Moreover, downregulation of JNK by its specific inhibitor SP600125 significantly diminished the anticancer activity of APE indicating that ROS generation and sustained JNK activation represented the main underlying mechanism of APE-induced cell death. APE also inhibited AKT activation and downregulated several oncoproteins, such as NF-kB, c-myc, and beta-catenin. In light of these results, APE may be an attractive candidate for drug development against triple negative breast cancer

Quantum Tests of the Einstein Equivalence Principle with the STE-QUEST Space Mission

We present in detail the scientific objectives in fundamental physics of the Space–Time Explorer and QUantum Equivalence Space Test (STE–QUEST) space mission. STE–QUEST was pre-selected by the European Space Agency together with four other missions for the cosmic vision M3 launch opportunity planned around 2024. It carries out tests of different aspects of the Einstein Equivalence Principle using atomic clocks, matter wave interferometry and long distance time/frequency links, providing fascinating science at the interface between quantum mechanics and gravitation that cannot be achieved, at that level of precision, in ground experiments. We especially emphasize the specific strong interest of performing Equivalence Principle tests in the quantum regime, i.e. using quantum atomic wave interferometry. Although STE–QUEST was finally not selected in early 2014 because of budgetary and technological reasons, its science case was very highly rated. Our aim is to expose that science to a large audience in order to allow future projects and proposals to take advantage of the STE–QUEST experience

Mobile Smart Grids: Exploiting the TV White Space in Urban Scenarios

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Phase angle and Mediterranean diet in patients with acne: Two easy tools for assessing the clinical severity of disease

Acne is a chronic, inflammatory and debilitating skin disorder. Dietary factors and nutritional status are among the exacerbating factors of acne. Phase angle (PhA), a direct measure of Bioelectrical Impedance Analysis (BIA), represents an indicator of the chronic inflammatory state. The Mediterranean diet (MD) is a healthy dietary pattern that can exert anti-inflammatory effects in several inflammatory diseases. We aimed to investigate the difference in PhA and adherence to the MD and their associations with the severity of acne in a sample of naïve treatment patients with acne compared to control group

A multi-frequency method to improve the long-term estimation of GNSS clock corrections and phase biases

The space segment of the Global Navigation Satellite System (GNSS) is equipped with highly stable atomic clocks. In order to use these clocks as references, their time offsets must be estimated from ground measurements as accurately as possible. This work presents a multi-frequency and multi-constellation method for estimating satellite and receiver clock corrections, starting from unambiguous, uncombined, and undifferenced carrier-phase measurements. A byproduct of the estimation process is phase biases (i.e., the hardware delays of the carrier-phase measurements occurring at receivers and satellites). The stability and predictability of our clock estimates for receivers and satellites (GPS and Galileo) are compared with those obtained by the International GNSS Service (IGS), whereas the phase biases are assessed against two independent determinations involving combinations of carrier-phase measurements. We conclude that the method reduces day boundary discontinuities in the clock corrections, and that the estimated phase biases reproduce variabilities already observed by other authors.The present work was supported in part by the Euro-pean Space Agency contract (REL-GAL) N.4000122402/17/NL/IB, by the project RTI2018-094295-B-I00 funded bytheMCIN/AEI10.13039/501100011033whichisco-foundedby the FEDER programme, and by the Horizon 2020 MarieSkłodowska-Curie Individual Global Fellowship 797461NAVSCIN. The authors acknowledge the use of data andproducts provided by the International GNSS ServicePeer ReviewedPostprint (published version

Metastasis-Directed Radiation Therapy with Consolidative Intent for Oligometastatic Urothelial Carcinoma: A Systematic Review and Meta-Analysis

The management of patients with oligometastatic urothelial carcinoma (UC) represents an evolving field in uro-oncology, and the role of metastasis-directed therapies, including metastasectomy and metastasis-directed radiation therapy (MDRT), is gaining increasing attention. Herein, we summarize available evidence about the role of MDRT with consolidative intent in oligometastatic UC patients. A systematic review was performed in December 2021. Six studies involving 158 patients were identified. Most patients (n = 120, 90.2%) had a history of bladder cancer and the most frequent sites of metastases were lymph nodes (n = 61, 52.1%) followed by the lungs (n = 34, 29%). Overall, 144 metastases were treated with MDRT. Median follow-up ranged from 17.2 to 25 months. Local control rates ranged from 57% to 100%. Median Overall Survival (OS) ranged from 14.9 to 51.0 months and median progression-free survival ranged from 2.9 to 10.1 months. Rates of OS at one and two years ranged from 78.9% to 96% and from 26% to 63%, respectively. Treatment-related toxicity was recorded in few patients and in most cases a low-grade toxicity was evident. MDRT with consolidative intent represents a potential treatment option for selected patients with oligometastatic UC